Role of mitochondrial dysfunction in Alzheimer's disease

J Neurosci Res. 2002 Nov 1;70(3):357-60. doi: 10.1002/jnr.10389.

Abstract

Abnormalities in mitochondrial function relate to the spectrum of pathological changes seen in Alzheimer's disease. Here we review the causes and consequences of mitochondrial disturbances in Alzheimer's disease as well as how this information might impact on therapeutic approaches to this disease.

Publication types

  • Review

MeSH terms

  • Alzheimer Disease / etiology
  • Alzheimer Disease / metabolism*
  • Alzheimer Disease / physiopathology
  • Animals
  • Brain / metabolism*
  • Brain / pathology
  • Brain / physiopathology
  • Cytochromes / deficiency
  • Cytochromes / genetics
  • DNA, Mitochondrial / genetics
  • Energy Metabolism / physiology
  • Humans
  • Mitochondria / metabolism*
  • Mitochondria / pathology
  • Mitochondrial Diseases / complications
  • Mitochondrial Diseases / metabolism*
  • Mitochondrial Diseases / physiopathology
  • Mutation / genetics
  • Neurons / metabolism*
  • Neurons / pathology
  • Oxidative Stress / physiology*

Substances

  • Cytochromes
  • DNA, Mitochondrial