Drugs, flies, and videotape: the effects of ethanol and cocaine on Drosophila locomotion

Adrian Rothenfluh; Ulrike Heberlein

doi:10.1016/s0959-4388(02)00380-x

Drugs, flies, and videotape: the effects of ethanol and cocaine on Drosophila locomotion

Curr Opin Neurobiol. 2002 Dec;12(6):639-45. doi: 10.1016/s0959-4388(02)00380-x.

Authors

Adrian Rothenfluh¹, Ulrike Heberlein

Affiliation

¹ Department of Anatomy, University of California at San Francisco, 513 Parnassus Avenue, 94143-0452, USA. adrianr@itsa.ucsf.edu

PMID: 12490253
DOI: 10.1016/s0959-4388(02)00380-x

Abstract

Drosophila melanogaster has been introduced recently as a model organism in which to study the mechanisms by which drugs of abuse change behavior and by which the nervous system changes upon repeated drug exposure. Surprising similarities between flies and mammals have begun to emerge at the behavioral, neurochemical and molecular levels.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

MeSH terms

Animals
Behavior, Animal / drug effects
Circadian Rhythm / physiology
Cocaine / pharmacology*
Cyclic AMP / metabolism
Dopamine / metabolism
Drosophila melanogaster
Drug Tolerance / physiology
Ethanol / pharmacology*
Locomotion / drug effects*

Substances

Ethanol
Cyclic AMP
Cocaine
Dopamine