Abstract
Alzheimer's disease (AD) is characterized by a progressive impairment of memory and intellectual functioning. The disease is a complex multi-factorial disease with the involvement of several possible genes. To study AD, a high-density cDNA array was developed to characterize the mRNA expression profile of 14160 genes. The preliminary results support the amyloid cascade hypothesis as the mechanism of the disease.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alcohol Oxidoreductases
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Alzheimer Disease / etiology
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Alzheimer Disease / genetics*
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Alzheimer Disease / metabolism
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Amyloid / genetics
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Amyloid / metabolism
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Brain / metabolism
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Case-Control Studies
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DNA-Binding Proteins / genetics
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Down-Regulation
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Gene Expression Profiling / methods*
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Humans
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Oligonucleotide Array Sequence Analysis / methods*
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Phosphoproteins / genetics
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Transforming Growth Factor beta / genetics
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Up-Regulation
Substances
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Amyloid
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DNA-Binding Proteins
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Phosphoproteins
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Transforming Growth Factor beta
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Alcohol Oxidoreductases
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C-terminal binding protein