Abstract
Phosphoinositide 3-kinases (PI3Ks) regulate numerous biological processes, including cell growth, differentiation, survival, proliferation, migration and metabolism. In the immune system, impaired PI3K signalling leads to immunodeficiency, whereas unrestrained PI3K signalling contributes to autoimmunity and leukaemia. New insights into the role of PI3Ks in lymphocyte biology have been derived from gene-targeting studies, which have identified the PI3K subunits that are involved in B-cell and T-cell signalling. In particular, the catalytic subunit p110delta seems to be adapted to transmit antigen-receptor signalling in B and T cells. Additional recent work has provided new insights into the molecular interactions that lead to PI3K activation and the signalling pathways that are regulated by PI3K.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Agammaglobulinaemia Tyrosine Kinase
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Animals
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B-Lymphocytes / cytology
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B-Lymphocytes / enzymology
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B-Lymphocytes / immunology
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CD28 Antigens / metabolism
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Cell Differentiation
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Enzyme Activation
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Gene Targeting
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Humans
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Lymphocyte Activation
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Lymphocytes / cytology
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Lymphocytes / enzymology*
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Lymphocytes / immunology*
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Mice
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Models, Immunological
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Phosphatidylinositol 3-Kinases / classification
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Phosphatidylinositol 3-Kinases / genetics
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Phosphatidylinositol 3-Kinases / immunology
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Phosphatidylinositol 3-Kinases / metabolism*
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Protein-Tyrosine Kinases / genetics
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Protein-Tyrosine Kinases / immunology
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Protein-Tyrosine Kinases / metabolism
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Signal Transduction
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T-Lymphocytes / cytology
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T-Lymphocytes / enzymology
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T-Lymphocytes / immunology
Substances
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CD28 Antigens
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Phosphatidylinositol 3-Kinases
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Protein-Tyrosine Kinases
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Agammaglobulinaemia Tyrosine Kinase