5-HT 2A receptor stimulation by DOI, a 5-HT 2A/2C receptor agonist, potentiates amphetamine-induced dopamine release in rat medial prefrontal cortex and nucleus accumbens

Brain Res. 2003 May 16;972(1-2):216-21. doi: 10.1016/s0006-8993(03)02516-2.

Abstract

(+/-)-([1-(2,5-Dimethoxy-4-iodophenyl)-aminopropane]-hydrochloride) (DOI) (2.5 mg/kg), a 5-HT(2A/2C) agonist, significantly potentiated D-amphetamine (AMPH) (1 mg/kg)-induced dopamine (DA) release in rat medial prefrontal cortex (mPFC) and nucleus accumbens (NAC). This effect of DOI was completely prevented by M100907 (1 mg/kg), a selective 5-HT(2A) antagonist, which by itself had no effect on basal and AMPH-induced DA release in either region. Thus, 5-HT(2A) receptor agonism potentiates AMPH-induced DA release in the mPFC and NAC.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amphetamine / pharmacology*
  • Animals
  • Central Nervous System Stimulants / pharmacology*
  • Dopamine / metabolism*
  • Dose-Response Relationship, Drug
  • Drug Interactions
  • Fluorobenzenes / pharmacology
  • Indophenol / analogs & derivatives*
  • Indophenol / pharmacology*
  • Male
  • Nucleus Accumbens / drug effects*
  • Nucleus Accumbens / metabolism
  • Piperidines / pharmacology
  • Prefrontal Cortex / drug effects*
  • Prefrontal Cortex / metabolism
  • Rats
  • Rats, Sprague-Dawley
  • Receptor, Serotonin, 5-HT2A
  • Receptors, Serotonin / metabolism*
  • Serotonin Antagonists
  • Serotonin Receptor Agonists / pharmacology*
  • Time Factors

Substances

  • Central Nervous System Stimulants
  • Fluorobenzenes
  • Piperidines
  • Receptor, Serotonin, 5-HT2A
  • Receptors, Serotonin
  • Serotonin Antagonists
  • Serotonin Receptor Agonists
  • dimethoxy-4-indophenyl-2-aminopropane
  • Indophenol
  • Amphetamine
  • volinanserin
  • Dopamine