Abstract
(+/-)-([1-(2,5-Dimethoxy-4-iodophenyl)-aminopropane]-hydrochloride) (DOI) (2.5 mg/kg), a 5-HT(2A/2C) agonist, significantly potentiated D-amphetamine (AMPH) (1 mg/kg)-induced dopamine (DA) release in rat medial prefrontal cortex (mPFC) and nucleus accumbens (NAC). This effect of DOI was completely prevented by M100907 (1 mg/kg), a selective 5-HT(2A) antagonist, which by itself had no effect on basal and AMPH-induced DA release in either region. Thus, 5-HT(2A) receptor agonism potentiates AMPH-induced DA release in the mPFC and NAC.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Amphetamine / pharmacology*
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Animals
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Central Nervous System Stimulants / pharmacology*
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Dopamine / metabolism*
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Dose-Response Relationship, Drug
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Drug Interactions
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Fluorobenzenes / pharmacology
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Indophenol / analogs & derivatives*
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Indophenol / pharmacology*
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Male
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Nucleus Accumbens / drug effects*
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Nucleus Accumbens / metabolism
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Piperidines / pharmacology
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Prefrontal Cortex / drug effects*
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Prefrontal Cortex / metabolism
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Rats
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Rats, Sprague-Dawley
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Receptor, Serotonin, 5-HT2A
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Receptors, Serotonin / metabolism*
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Serotonin Antagonists
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Serotonin Receptor Agonists / pharmacology*
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Time Factors
Substances
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Central Nervous System Stimulants
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Fluorobenzenes
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Piperidines
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Receptor, Serotonin, 5-HT2A
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Receptors, Serotonin
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Serotonin Antagonists
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Serotonin Receptor Agonists
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dimethoxy-4-indophenyl-2-aminopropane
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Indophenol
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Amphetamine
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volinanserin
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Dopamine