Nuclear receptors orchestrate detoxification pathways

Dev Cell. 2003 May;4(5):607-8. doi: 10.1016/s1534-5807(03)00131-x.

Abstract

Two nuclear receptors of xenobiotic drugs, PXR and CAR, are central regulators of detoxification enzymes. New studies extend the role of these receptors to a natural detoxification process. They coordinate induction of proteins for storage, glucuronidation, and canalicular transport of bilirubin.

Publication types

  • Comment

MeSH terms

  • Animals
  • Bilirubin / metabolism
  • Constitutive Androstane Receptor
  • Glucuronosyltransferase / metabolism
  • Humans
  • Inactivation, Metabolic
  • Pregnane X Receptor
  • Receptors, Cytoplasmic and Nuclear / metabolism*
  • Receptors, Steroid / metabolism*
  • Transcription Factors / metabolism*

Substances

  • Constitutive Androstane Receptor
  • Pregnane X Receptor
  • Receptors, Cytoplasmic and Nuclear
  • Receptors, Steroid
  • Transcription Factors
  • UGT1A1 enzyme
  • Glucuronosyltransferase
  • Bilirubin