Abstract
We describe the effects of 5'-N-ethylcarboxamidoadenosine (NECA), a mixed A2a/A2b adenosine receptor agonist and 2-[p-(carboxyethyl)-phenylethylamino]-5'-N-ethylcarboxamidoaden osin e (CGS 21680), a selective A2a agonist, on cyclic AMP and N-acetylserotonin synthesis in rat pineal gland. NECA, 1 and 10 microM, increased cyclic AMP by 5- and 25-fold and N-acetylserotonin by 40- and 60-fold respectively, whereas CGS 21680 at the same concentrations was ineffective. These results argue for the presence of adenosine A2b receptors in rat pinealocytes.
MeSH terms
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Adenosine / analogs & derivatives
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Adenosine / pharmacology
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Adenosine-5'-(N-ethylcarboxamide)
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Animals
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Cyclic AMP / biosynthesis*
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Organ Culture Techniques
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Phenethylamines / pharmacology
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Pineal Gland / drug effects
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Pineal Gland / metabolism*
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Rats
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Receptors, Purinergic / metabolism*
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Serotonin / analogs & derivatives*
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Serotonin / biosynthesis
Substances
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Phenethylamines
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Receptors, Purinergic
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2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine
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Serotonin
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Adenosine-5'-(N-ethylcarboxamide)
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Cyclic AMP
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Adenosine
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N-acetylserotonin