Abstract
Cannabinoid receptor ligands irreversibly inhibited peak voltage-activated Ca currents (44%) in NG108-15 cells; this inhibition was Pertussis toxin-sensitive. Inhibition was largely due to a reduction in the omega-conotoxin sensitive portion of high-voltage activated (HVA) current, although there was also a significant decrease in low-voltage activated current (56%) and in the nifedipine-sensitive portion of HVA current (41%).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Analgesics / pharmacology
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Calcium Channel Blockers / pharmacology*
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Cannabinoids / pharmacology*
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Cyclohexanols / pharmacology
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Dronabinol / pharmacology
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GTP-Binding Proteins / metabolism
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Humans
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Neuroblastoma / metabolism*
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Peptides, Cyclic / pharmacology
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Pertussis Toxin*
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Receptors, Cannabinoid
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Receptors, Drug / drug effects*
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Tumor Cells, Cultured / drug effects
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Tumor Cells, Cultured / metabolism
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Virulence Factors, Bordetella / pharmacology*
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omega-Conotoxins*
Substances
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Analgesics
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Calcium Channel Blockers
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Cannabinoids
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Cyclohexanols
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Peptides, Cyclic
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Receptors, Cannabinoid
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Receptors, Drug
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Virulence Factors, Bordetella
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omega-Conotoxins
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Conus magus toxin
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Dronabinol
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3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol
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Pertussis Toxin
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GTP-Binding Proteins