Abstract
We have characterized PPADS (pyridoxalphosphate-6-azophenyl-2',4'-disulfonic acid) as a novel antagonist which selectively blocks P2 purinoceptor-mediated responses in rabbit vas deferens at pre- and postjunctional sites. PPADS did not interact with alpha 1-adrenoceptors, muscarinic M2 and M3 receptors, histamine H1 and adenosine A1 receptors. Thus, PPADS is a novel and useful pharmacological tool to study co-transmission in tissues where ATP and co-existing neurotransmitters act in concert.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Adenosine Triphosphate / metabolism
-
Animals
-
Electric Stimulation
-
Male
-
Prazosin / pharmacology
-
Purinergic Antagonists*
-
Pyridoxal Phosphate / analogs & derivatives*
-
Pyridoxal Phosphate / pharmacology
-
Rabbits
-
Synaptic Transmission / drug effects*
-
Vas Deferens / drug effects
-
Vas Deferens / innervation
Substances
-
Purinergic Antagonists
-
pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid
-
Pyridoxal Phosphate
-
Adenosine Triphosphate
-
Prazosin