Abstract
The suicide transport agent volkensin was used to produce a selective lesion of striatonigral projection neurons and the time course of changes in binding at striatal D1 and D2 receptors analyzed. Both show a time-dependent decrease with two-thirds of the total change occurring within the first 10 days and a greater decrease in D1 receptor density at all time points. Our results confirm selective localization of D1 receptors to striatonigral neurons and are consistent with localization of some striatal D2 receptors to striatonigral neurons.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Autoradiography
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Binding Sites / drug effects
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Corpus Striatum / cytology
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Corpus Striatum / metabolism*
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Corpus Striatum / physiology
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Glycoproteins*
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Male
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N-Glycosyl Hydrolases*
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Neurons / drug effects
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Neurons / physiology
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Plant Lectins*
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Plant Proteins / pharmacology
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Rats
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Rats, Sprague-Dawley
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Receptors, Dopamine D1 / drug effects
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Receptors, Dopamine D1 / metabolism*
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Receptors, Dopamine D2 / drug effects
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Receptors, Dopamine D2 / metabolism*
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Regression Analysis
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Ribosome Inactivating Proteins, Type 2
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Substantia Nigra / cytology
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Substantia Nigra / physiology*
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Synaptic Transmission / physiology
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Time Factors
Substances
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Glycoproteins
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Plant Lectins
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Plant Proteins
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Receptors, Dopamine D1
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Receptors, Dopamine D2
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Ribosome Inactivating Proteins, Type 2
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volkensin
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N-Glycosyl Hydrolases