Abstract
Rhesus monkeys were trained to lever press for infusions of cocaine during daily, 1-h experimental sessions. Following stabilization of the cocaine-maintained baselines, various antihistamines were substituted for cocaine to determine whether they would be self-administered. The results indicated that all monkeys tested self-administered tripelennamine and chlorpheniramine. One monkey out of the four self-administered pyrilamine, but only at a single (300 microgram/kg) high dose. Phenyltoloxamine, cimetidine and hydroxyzine were not self-administered. These results further illuminate differences amongst H1 antagonists in their potential for self-administration and, when examined in context with other reports, suggest that stimulant-like properties may help mediate their reinforcing effects when present.
Publication types
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Comparative Study
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Benzhydryl Compounds / administration & dosage
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Benzhydryl Compounds / toxicity
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Chlorpheniramine / administration & dosage
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Chlorpheniramine / toxicity
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Cimetidine / administration & dosage
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Cimetidine / toxicity
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Dose-Response Relationship, Drug
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Histamine H1 Antagonists / administration & dosage*
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Histamine H1 Antagonists / toxicity
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Hydroxyzine / administration & dosage
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Hydroxyzine / toxicity
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Macaca mulatta
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Male
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Motivation
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Pyrilamine / administration & dosage
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Pyrilamine / toxicity
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Self Administration
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Substance-Related Disorders / etiology*
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Tripelennamine / administration & dosage
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Tripelennamine / toxicity
Substances
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Benzhydryl Compounds
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Histamine H1 Antagonists
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Hydroxyzine
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Tripelennamine
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Chlorpheniramine
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Cimetidine
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Pyrilamine
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phenyltoloxamine