Abstract
Nitric oxide is a diffusible molecule with profound effects on regulated exocytosis in several biological systems-however, the molecular targets remain elusive. In this issue of Cell, Matsushita et al. report that in aortic endothelial cells, S-nitrosylation of NSF, an ATPase essential for the activation of the membranefusion machinery, inhibits the exocytosis of Weibel-Palade bodies, secretory granules containing a cocktail of mediators essential to the regulation of vascular vessel tone.
Publication types
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Comparative Study
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Comment
MeSH terms
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Amino Acid Sequence
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Aorta / cytology
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Carrier Proteins / chemistry
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Carrier Proteins / metabolism*
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Cell Membrane / metabolism*
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Cells, Cultured
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Conserved Sequence
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Cysteine / metabolism
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Endothelium, Vascular / cytology
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Endothelium, Vascular / drug effects
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Endothelium, Vascular / metabolism
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Exocytosis*
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Humans
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Molecular Sequence Data
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N-Ethylmaleimide-Sensitive Proteins
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Nitric Oxide / biosynthesis
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Nitric Oxide / pharmacology*
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Vesicular Transport Proteins*
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Weibel-Palade Bodies / metabolism
Substances
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Carrier Proteins
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Vesicular Transport Proteins
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Nitric Oxide
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N-Ethylmaleimide-Sensitive Proteins
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Cysteine