Abstract
During the past fifteen years, a variety of peptides have been characterized for their ability to translocate into live cells. Most are efficient vectors that can internalize hydrophilic cargoes, and so provide a valuable biological (and potentially therapeutic) tool for targeting proteins into cells. Furthermore, translocation of cell-permeable peptides across the plasma membrane and their subsequent access to the cytosol, even when fused to large hydrophilic proteins, is challenging the perception of the plasma membrane as an impermeable barrier.
Publication types
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
Animals
-
Cell Membrane / drug effects*
-
Cell Membrane / metabolism
-
Cell Membrane Permeability / drug effects
-
Cell Membrane Permeability / physiology
-
Genetic Vectors / physiology
-
Humans
-
Peptides / metabolism*
-
Peptides / pharmacokinetics*
-
Protein Engineering / methods
-
Protein Engineering / trends
-
Protein Structure, Tertiary / physiology
-
Protein Transport / drug effects*
-
Protein Transport / physiology
-
Recombinant Fusion Proteins / metabolism
-
Recombinant Fusion Proteins / pharmacokinetics
-
Transduction, Genetic / methods*
-
Transduction, Genetic / trends
Substances
-
Peptides
-
Recombinant Fusion Proteins