Not just a sink: endosomes in control of signal transduction

Marta Miaczynska; Lucas Pelkmans; Marino Zerial

doi:10.1016/j.ceb.2004.06.005

Not just a sink: endosomes in control of signal transduction

Curr Opin Cell Biol. 2004 Aug;16(4):400-6. doi: 10.1016/j.ceb.2004.06.005.

Authors

Marta Miaczynska¹, Lucas Pelkmans, Marino Zerial

Affiliation

¹ Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany. miaczynska@mpi-cbg.de

PMID: 15261672
DOI: 10.1016/j.ceb.2004.06.005

Abstract

Recent studies indicate that endocytic organelles can play a more active role in signal propagation and amplification than was recognised before. By deciphering the interplay between endocytosis and signalling, we will be able to gain a more sophisticated level of understanding of signal transduction mechanisms.

Publication types

Review

MeSH terms

Animals
Endocytosis*
Endosomes / metabolism*
Epidermal Growth Factor / metabolism
ErbB Receptors / metabolism
GTP-Binding Proteins / metabolism
Humans
Ligands
Lysosomes / metabolism
Models, Biological
Nerve Growth Factor / metabolism
Protein Transport
Receptors, G-Protein-Coupled / metabolism
Receptors, Transforming Growth Factor beta / metabolism
Signal Transduction*
Transforming Growth Factor beta / metabolism

Substances

Ligands
Receptors, G-Protein-Coupled
Receptors, Transforming Growth Factor beta
Transforming Growth Factor beta
Epidermal Growth Factor
Nerve Growth Factor
ErbB Receptors
GTP-Binding Proteins