Severe metabolic acidosis and renal failure in an HIV-1 patient receiving tenofovir

Scand J Infect Dis. 2004;36(5):389-92. doi: 10.1080/00365540410027157.

Abstract

A 55-y-old male developed severe metabolic acidosis and renal failure during tenofovir therapy. Increased tenofovir exposure due to low body weight and chronic stable renal insufficiency could have enhanced the risk of nephrotoxicity, and creatinine clearance should be estimated before initiation of tenofovir.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Acidosis, Lactic / chemically induced*
  • Acidosis, Lactic / complications
  • Acidosis, Lactic / physiopathology
  • Acute Kidney Injury / chemically induced*
  • Acute Kidney Injury / complications
  • Acute Kidney Injury / physiopathology
  • Adenine / administration & dosage*
  • Adenine / analogs & derivatives*
  • Adenine / therapeutic use
  • HIV Infections / complications
  • HIV Infections / diagnosis
  • HIV Infections / drug therapy*
  • Humans
  • Kidney Function Tests
  • Male
  • Middle Aged
  • Organophosphonates*
  • Organophosphorus Compounds / administration & dosage*
  • Organophosphorus Compounds / therapeutic use
  • Prognosis
  • Reverse Transcriptase Inhibitors / adverse effects*
  • Reverse Transcriptase Inhibitors / therapeutic use
  • Risk Assessment
  • Severity of Illness Index
  • Tenofovir

Substances

  • Organophosphonates
  • Organophosphorus Compounds
  • Reverse Transcriptase Inhibitors
  • Tenofovir
  • Adenine