Regulation of protein kinases; controlling activity through activation segment conformation

Brad Nolen; Susan Taylor; Gourisankar Ghosh

doi:10.1016/j.molcel.2004.08.024

Regulation of protein kinases; controlling activity through activation segment conformation

Mol Cell. 2004 Sep 10;15(5):661-75. doi: 10.1016/j.molcel.2004.08.024.

Authors

Brad Nolen¹, Susan Taylor, Gourisankar Ghosh

Affiliation

¹ Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92116, USA.

PMID: 15350212
DOI: 10.1016/j.molcel.2004.08.024

Abstract

There are currently at least forty-six unique protein kinase crystal structures, twenty-four of which are available in an active state. Here we examine these structures using a structural bioinformatics approach to understand how the conformation of the activation segment controls kinase activity.

Publication types

Review

MeSH terms

Amino Acid Motifs / physiology
Animals
Catalytic Domain / physiology
Computational Biology
Humans
Models, Molecular
Molecular Conformation*
Phosphorylation
Protein Kinases / chemistry*
Protein Structure, Tertiary / physiology
Sequence Homology, Amino Acid
Structure-Activity Relationship

Substances

Protein Kinases