Abstract
The interaction of 4-hydroxynonenal (HNE) with a variety of kinases variously involved in cell signaling is now a matter of active investigation. In particular, findings with regard to the effect of HNE on different components of the protein kinase C family and the mitogen-activated protein kinase complex already provide reliable indications of a potential role of this aldehyde as a cell signal messenger. Such a role appears further supported by the clear-cut evidence of up-regulation of receptor tyrosine kinases and down-regulation of the nuclear factor kappa B system, produced by HNE concentrations actually detectable in pathophysiology.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Aldehydes / chemistry
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Aldehydes / pharmacology*
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Animals
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Down-Regulation
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Humans
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I-kappa B Kinase
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Protein Serine-Threonine Kinases / drug effects*
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Protein Serine-Threonine Kinases / metabolism
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Protein Serine-Threonine Kinases / physiology
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Receptor Protein-Tyrosine Kinases / drug effects*
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Receptor Protein-Tyrosine Kinases / physiology
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Signal Transduction / drug effects*
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Up-Regulation
Substances
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Aldehydes
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Receptor Protein-Tyrosine Kinases
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Protein Serine-Threonine Kinases
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CHUK protein, human
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I-kappa B Kinase
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IKBKB protein, human
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IKBKE protein, human
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4-hydroxy-2-nonenal