Abstract
The vagus nerve forms a neuro-anatomical link between the gastrointestinal tract and the brain. A number of gastrointestinal hormones, including cholecystokinin and ghrelin, require an intact vagal-brainstem-hypothalamic pathway to affect CNS feeding circuits. We have shown that the effects of peripheral administration of both peptide YY(3-36) (PYY(3-36)) and glucagon-like peptide-1 (GLP-1) on food intake and activation of hypothalamic arcuate feeding neurones are abolished following either bilateral sub-diaphragmatic total truncal vagotomy or brainstem-hypothalamic pathway transectioning in rodents. These findings suggest that the vagal-brainstem-hypothalamic pathway may also play a role in the effects of circulating PYY(3-36) and GLP-1 on food intake.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Brain Stem / drug effects*
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Brain Stem / physiology
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Denervation / methods
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Eating / drug effects*
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Efferent Pathways / drug effects
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Efferent Pathways / physiology
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Hypothalamus / drug effects*
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Hypothalamus / physiology
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Inhibition, Psychological
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Intercellular Signaling Peptides and Proteins
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Male
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Naphthalenes
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Oxepins
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Peptide Fragments
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Peptide YY / administration & dosage*
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Peptides / administration & dosage*
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Rats
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Rats, Wistar
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Vagotomy / methods
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Vagus Nerve / drug effects*
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Vagus Nerve / physiology
Substances
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1-phenyl-1,4-epoxy-1H,4H-naphtho(1,8-de)(1,2)dioxepin
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Intercellular Signaling Peptides and Proteins
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Naphthalenes
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Oxepins
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Peptide Fragments
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Peptides
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Peptide YY
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peptide YY (3-36)
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glucagon releasing peptide