Replication of action of cholecystokinin tetrapeptide in panic disorder: clinical and behavioral findings

J Bradwejn; D Koszycki; R Payeur; M Bourin; H Borthwick

doi:10.1176/ajp.149.7.962

Replication of action of cholecystokinin tetrapeptide in panic disorder: clinical and behavioral findings

Am J Psychiatry. 1992 Jul;149(7):962-4. doi: 10.1176/ajp.149.7.962.

Authors

J Bradwejn¹, D Koszycki, R Payeur, M Bourin, H Borthwick

Affiliation

¹ Division of Psychopharmacology, St. Mary's Hospital Center, Montreal, PQ, Canada.

PMID: 1609879
DOI: 10.1176/ajp.149.7.962

Abstract

Eleven patients with panic disorder were challenged with cholecystokinin tetrapeptide (CCK-4) on two occasions. The effects of CCK-4 were consistent except symptom onset was more rapid with the second injection. Demonstrating that the effects of CCK-4 are reproducible in panic patients opens the doors for studies of the effects of drug treatment on CCK-4-induced panic.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Female
Humans
Injections, Intravenous
Male
Middle Aged
Panic Disorder / chemically induced*
Panic Disorder / psychology
Personality Inventory
Placebos
Reproducibility of Results
Severity of Illness Index
Tetragastrin* / administration & dosage
Tetragastrin* / pharmacology

Substances

Placebos
Tetragastrin