Abstract
Specific and quantitative analyses of the bioactive components and their metabolites in body fluids are essential to assess the interaction between groups of compounds in dietary supplements and preparations of psychoactives. Reverse-phase LC separations combined with tandem mass spectrometry provide the necessary specificity and sensitivity. In this paper, applications of these methods are described for the analysis of isoflavones, salvinorin A, synephrine isomers and their metabolites in serum, urine and aqueous humor.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Chromatography, Liquid
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Dietary Supplements*
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Diterpenes / analysis
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Diterpenes / metabolism
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Diterpenes / pharmacokinetics
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Diterpenes, Clerodane
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Dogs
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Flavonoids / chemistry*
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Flavonoids / metabolism*
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Flavonoids / pharmacokinetics
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Mass Spectrometry
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Phenols / chemistry*
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Phenols / metabolism*
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Phenols / pharmacokinetics
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Polyphenols
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Psychotropic Drugs / chemistry
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Psychotropic Drugs / metabolism
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Spectrometry, Mass, Electrospray Ionization
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Synephrine / analysis
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Synephrine / metabolism
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Synephrine / pharmacokinetics
Substances
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Diterpenes
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Diterpenes, Clerodane
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Flavonoids
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Phenols
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Polyphenols
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Psychotropic Drugs
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Synephrine
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salvinorin A