Abstract
Continuous subcutaneous administration of naloxone (3 mg/kg/h), shifted ventral tegmental self-stimulation rate-frequency curves to the right, without suppressing behavioral performance. In addition this chronic blockade of opioid receptors altered mu binding parameters in the hippocampus and olfactory tubercle of naloxone-treated animals. These findings speak to the role opioid peptides paly in the mediation of brain stimulation reward.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Brain / metabolism
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Enkephalin, Ala(2)-MePhe(4)-Gly(5)-
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Enkephalins / metabolism
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Injections, Subcutaneous
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Male
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Naloxone / pharmacology*
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Osmolar Concentration
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Rats
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Rats, Inbred Strains
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Receptors, Opioid / metabolism
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Receptors, Opioid, mu
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Self Stimulation*
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Tegmentum Mesencephali / physiology*
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Time Factors
Substances
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Enkephalins
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Receptors, Opioid
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Receptors, Opioid, mu
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Enkephalin, Ala(2)-MePhe(4)-Gly(5)-
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Naloxone