Abstract
Injections of 3,4-methylenedioxymethamphetamine (MDMA, 25 mg/kg, i.p.) to rats lead to an accumulation of c-fos protein (Fos) and Fos-related antigens in caudate-putamen, nucleus accumbens and olfactory tubercle. This induction occurred at least 2 h (but not at 10 min) after injection and Fos levels had returned to baseline after 24 h, although Fos-related antigens remained elevated 24 h after injection. The NMDA antagonist MK 801 inhibited Fos and Fos-related antigen induction after MDMA injections, whereas fluoxetine, a serotonin uptake inhibitor, had no effect. Thus, MDMA induces Fos and Fos-related antigens in striatal neurons in an NMDA-reversible fashion.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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3,4-Methylenedioxyamphetamine / analogs & derivatives*
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3,4-Methylenedioxyamphetamine / antagonists & inhibitors
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3,4-Methylenedioxyamphetamine / pharmacology
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Animals
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Basal Ganglia / drug effects
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Basal Ganglia / metabolism*
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Caudate Nucleus / metabolism
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Corpus Striatum / drug effects
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Corpus Striatum / metabolism
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Dizocilpine Maleate / pharmacology*
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Fluoxetine / pharmacology
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Male
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N-Methyl-3,4-methylenedioxyamphetamine
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Nucleus Accumbens / drug effects
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Nucleus Accumbens / metabolism
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Olfactory Bulb / drug effects
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Olfactory Bulb / metabolism
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Proto-Oncogene Proteins / biosynthesis*
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Proto-Oncogene Proteins / immunology
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Proto-Oncogene Proteins c-fos
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Putamen / metabolism
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Rats
Substances
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Proto-Oncogene Proteins
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Proto-Oncogene Proteins c-fos
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Fluoxetine
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3,4-Methylenedioxyamphetamine
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Dizocilpine Maleate
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N-Methyl-3,4-methylenedioxyamphetamine