Abstract
Signalling through the ERBB/HER receptors is intricately involved in human cancer and already serves as a target for several cancer drugs. Because of its inherent complexity, it is useful to envision ERBB signalling as a bow-tie-configured, evolvable network, which shares modularity, redundancy and control circuits with robust biological and engineered systems. Because network fragility is an inevitable trade-off of robustness, systems-level understanding is expected to generate therapeutic opportunities to intercept aberrant network activation.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Endocytosis / physiology
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Epidermal Growth Factor / metabolism*
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ErbB Receptors / chemistry
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ErbB Receptors / genetics
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ErbB Receptors / metabolism
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Feedback, Physiological
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Humans
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Ligands
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Models, Molecular
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Oncogene Proteins v-erbB / genetics
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Oncogene Proteins v-erbB / metabolism*
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Phosphatidylinositol 3-Kinases / metabolism
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Protein Conformation
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Signal Transduction / physiology*
Substances
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Ligands
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Oncogene Proteins v-erbB
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Epidermal Growth Factor
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Phosphatidylinositol 3-Kinases
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ErbB Receptors