Abstract
The realization that there existed a G-protein coupled signal transduction mechanism developed gradually and was initially the result of an ill fated quest for uncovering the mechanism of action of insulin, followed by a refocused research in many laboratories, including mine, on how GTP acted to increase hormonal stimulation of adenylyl cyclase. Independent research into how light-activated rhodopsin triggers a response in photoreceptor cells of the retina and the attendant biochemical studies joined midway and, without the left hand knowing well what the right hand was doing, preceded classical G protein research in identifying the molecular players responsible for signal transduction by G proteins.
Publication types
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Historical Article
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Research Support, N.I.H., Intramural
MeSH terms
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Adenylyl Cyclases / drug effects
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Adenylyl Cyclases / history
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Adenylyl Cyclases / metabolism
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Animals
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Binding Sites
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Cholera Toxin / history
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Cholera Toxin / metabolism
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GTP Phosphohydrolases / metabolism
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GTP-Binding Protein alpha Subunits, Gi-Go / history
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GTP-Binding Protein alpha Subunits, Gi-Go / metabolism
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GTP-Binding Protein alpha Subunits, Gs / history
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GTP-Binding Protein alpha Subunits, Gs / metabolism
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Guanine Nucleotides / history
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Guanine Nucleotides / metabolism
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Heterotrimeric GTP-Binding Proteins / genetics
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Heterotrimeric GTP-Binding Proteins / history*
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Heterotrimeric GTP-Binding Proteins / metabolism
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History, 20th Century
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History, 21st Century
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Pertussis Toxin / history
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Pertussis Toxin / metabolism
Substances
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Guanine Nucleotides
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Cholera Toxin
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Pertussis Toxin
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GTP Phosphohydrolases
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GTP-Binding Protein alpha Subunits, Gi-Go
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GTP-Binding Protein alpha Subunits, Gs
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Heterotrimeric GTP-Binding Proteins
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Adenylyl Cyclases