Opioid tolerance and hyperalgesia

Grace Chang; Lucy Chen; Jianren Mao

doi:10.1016/j.mcna.2006.10.003

Opioid tolerance and hyperalgesia

Med Clin North Am. 2007 Mar;91(2):199-211. doi: 10.1016/j.mcna.2006.10.003.

Authors

Grace Chang¹, Lucy Chen, Jianren Mao

Affiliation

¹ Massachusetts General Hospital Pain Center, Division of Pain Medicine, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

PMID: 17321281
DOI: 10.1016/j.mcna.2006.10.003

Abstract

Opioids have been successfully used for the management of acute and cancer-related pain. Concerns regarding side effects, tolerance, dependence, addiction, and hyperalgesia have limited the use of opioids for the management of chronic nonmalignant pain. This article will review updated information from both clinical and preclinical studies regarding opioid-induced hyperalgesia, tolerance, and dependence. The implications of these issues in clinical opioid therapy also will be discussed.

Publication types

Review

MeSH terms

Analgesics, Opioid / adverse effects
Analgesics, Opioid / pharmacology*
Chronic Disease
Drug Tolerance*
Humans
Hyperalgesia / chemically induced*
Nociceptors / drug effects
Risk Factors
Substance-Related Disorders*

Substances

Analgesics, Opioid