Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose-response framework

Toxicol Appl Pharmacol. 2007 Jul 1;222(1):122-8. doi: 10.1016/j.taap.2007.02.015. Epub 2007 Mar 7.

Abstract

Many biological subdisciplines that regularly assess dose-response relationships have identified an evolutionarily conserved process in which a low dose of a stressful stimulus activates an adaptive response that increases the resistance of the cell or organism to a moderate to severe level of stress. Due to a lack of frequent interaction among scientists in these many areas, there has emerged a broad range of terms that describe such dose-response relationships. This situation has become problematic because the different terms describe a family of similar biological responses (e.g., adaptive response, preconditioning, hormesis), adversely affecting interdisciplinary communication, and possibly even obscuring generalizable features and central biological concepts. With support from scientists in a broad range of disciplines, this article offers a set of recommendations we believe can achieve greater conceptual harmony in dose-response terminology, as well as better understanding and communication across the broad spectrum of biological disciplines.

Publication types

  • Review

MeSH terms

  • Adaptation, Physiological*
  • Animals
  • Biology*
  • Dose-Response Relationship, Drug*
  • Humans
  • Stress, Physiological*
  • Terminology as Topic*