Effect of dipeptide N-acetylaspartylglutamate on denervation-induced changes in the volume of rat skeletal muscle fibers

Bull Exp Biol Med. 2006 Dec;142(6):683-4. doi: 10.1007/s10517-006-0450-3.
[Article in English, Russian]

Abstract

N-acetylaspartylglutamate prevents the denervation-induced increase in the volume of muscle fibers in rat diaphragm, the phenomenon being more pronounced for the hydrolysable isomer. The effect of dipeptide manifested against the background of blockade of metabotropic glutamate receptors. It was hypothesized that N-acetylaspartylglutamate is involved in the regulation of the volume of skeletal muscle fibers via activation of ionotropic receptors by both dipeptide and glutamate molecules.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Size / drug effects*
  • Dipeptides / pharmacology*
  • Excitatory Amino Acid Agonists / pharmacology
  • Excitatory Amino Acid Antagonists / pharmacology
  • Glutamates / pharmacology
  • Male
  • Muscle Denervation
  • Muscle Fibers, Skeletal / cytology
  • Muscle Fibers, Skeletal / drug effects*
  • Muscle Fibers, Skeletal / metabolism
  • Muscle, Skeletal / cytology*
  • Muscle, Skeletal / innervation
  • Muscle, Skeletal / metabolism
  • N-Methylaspartate / pharmacology
  • Neurosurgical Procedures
  • Rats
  • Receptors, Metabotropic Glutamate / agonists
  • Receptors, Metabotropic Glutamate / antagonists & inhibitors
  • Receptors, Metabotropic Glutamate / physiology

Substances

  • Dipeptides
  • Excitatory Amino Acid Agonists
  • Excitatory Amino Acid Antagonists
  • Glutamates
  • Receptors, Metabotropic Glutamate
  • isospaglumic acid
  • N-Methylaspartate