Abstract
There is strong evidence for the existence of Gq/11-coupled dopamine receptors in the brain but the mechanism by which dopamine signaling activates Gq/11, or its roles in neuronal function, are only just beginning to be understood. The importance of such a pathway is underlined by putative links between dopamine-regulated phosphoinositide signaling and several central nervous system disorders that include schizophrenia, addiction and Parkinson's disease.
MeSH terms
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Animals
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Dopamine / pharmacology
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Dopamine / physiology*
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GTP-Binding Protein alpha Subunits, Gq-G11 / metabolism*
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GTP-Binding Protein alpha Subunits, Gq-G11 / physiology
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Humans
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Models, Biological
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Neurons / chemistry*
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Neurons / drug effects
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Neurons / physiology
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Receptors, Dopamine D1 / agonists
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Receptors, Dopamine D1 / metabolism
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Receptors, Dopamine D1 / physiology
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Receptors, G-Protein-Coupled / metabolism*
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Receptors, G-Protein-Coupled / physiology
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Signal Transduction / drug effects
Substances
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Receptors, Dopamine D1
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Receptors, G-Protein-Coupled
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GTP-Binding Protein alpha Subunits, Gq-G11
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Dopamine