Neuronal Gq/11-coupled dopamine receptors: an uncharted role for dopamine

Trends Pharmacol Sci. 2007 Nov;28(11):551-5. doi: 10.1016/j.tips.2007.10.001. Epub 2007 Oct 22.

Abstract

There is strong evidence for the existence of Gq/11-coupled dopamine receptors in the brain but the mechanism by which dopamine signaling activates Gq/11, or its roles in neuronal function, are only just beginning to be understood. The importance of such a pathway is underlined by putative links between dopamine-regulated phosphoinositide signaling and several central nervous system disorders that include schizophrenia, addiction and Parkinson's disease.

Publication types

  • Review

MeSH terms

  • Animals
  • Dopamine / pharmacology
  • Dopamine / physiology*
  • GTP-Binding Protein alpha Subunits, Gq-G11 / metabolism*
  • GTP-Binding Protein alpha Subunits, Gq-G11 / physiology
  • Humans
  • Models, Biological
  • Neurons / chemistry*
  • Neurons / drug effects
  • Neurons / physiology
  • Receptors, Dopamine D1 / agonists
  • Receptors, Dopamine D1 / metabolism
  • Receptors, Dopamine D1 / physiology
  • Receptors, G-Protein-Coupled / metabolism*
  • Receptors, G-Protein-Coupled / physiology
  • Signal Transduction / drug effects

Substances

  • Receptors, Dopamine D1
  • Receptors, G-Protein-Coupled
  • GTP-Binding Protein alpha Subunits, Gq-G11
  • Dopamine