Abstract
Type II collagen (CII) is expressed exclusively in the joint articular. Although the relationship between anti-CII immunity and human rheumatoid arthritis (RA) has been studied for a long time, definitive conclusions have not been reached. CII, as an autoantigen, has been studied extensively in small animal models, such as mice, and the collagen-induced arthritis (CIA) model has increased our understanding of the pathogenesis of human RA. In the present report, we summarize the available information on anti-CII immunity and discuss recent updates regarding pathogenesis in the CIA model, including the role of Th17 cells.
MeSH terms
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Animals
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Arthritis, Experimental / immunology*
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Arthritis, Experimental / physiopathology
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Arthritis, Rheumatoid / immunology*
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Arthritis, Rheumatoid / physiopathology
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Autoantibodies / blood*
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Autoantigens / immunology*
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Autoimmunity
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CD4-Positive T-Lymphocytes / immunology
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CD4-Positive T-Lymphocytes / metabolism
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Cartilage / physiopathology
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Collagen Type II / immunology*
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Collagen Type II / metabolism
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Cytokines / immunology
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Cytokines / metabolism
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Dendritic Cells / immunology
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Dendritic Cells / metabolism
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Disease Models, Animal
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Inflammation Mediators / immunology
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Inflammation Mediators / metabolism
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Osteoclasts / physiology
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T-Lymphocytes, Regulatory / immunology
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T-Lymphocytes, Regulatory / metabolism
Substances
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Autoantibodies
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Autoantigens
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Collagen Type II
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Cytokines
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Inflammation Mediators