Psychosis in a 12-year-old HIV-positive girl with an increased serum concentration of efavirenz

Elizabeth A Lowenhaupt; Kelly Matson; Bushra Qureishi; Akihiko Saitoh; David Pugatch

doi:10.1086/522764

Psychosis in a 12-year-old HIV-positive girl with an increased serum concentration of efavirenz

Clin Infect Dis. 2007 Nov 15;45(10):e128-30. doi: 10.1086/522764. Epub 2007 Oct 5.

Authors

Elizabeth A Lowenhaupt¹, Kelly Matson, Bushra Qureishi, Akihiko Saitoh, David Pugatch

Affiliation

¹ Department of Psychiatry and Human Behavior, Brown Medical School, Providence, RI, USA. elowenhaupt@post.harvard.edu

PMID: 17968817
DOI: 10.1086/522764

Abstract

Clearance and adverse effects of efavirenz are associated with CYP2B6-G516T polymorphism. Little is known about the prevalence of genotypes and implications for screening in children. We report (to our knowledge, for the first time in a child) the emergence of psychosis in a 12-year old white girl with an increased efavirenz concentration and heterozygous gene polymorphism of the CYP2B6-G516T.

Publication types

Case Reports

MeSH terms

Alkynes
Aryl Hydrocarbon Hydroxylases / genetics
Benzoxazines / adverse effects*
Benzoxazines / blood
Benzoxazines / therapeutic use
Child
Cyclopropanes
Cytochrome P-450 CYP2B6
Female
HIV Infections / complications*
HIV Infections / drug therapy
Heterozygote
Humans
Oxidoreductases, N-Demethylating / genetics
Point Mutation
Psychoses, Substance-Induced / etiology*
Reverse Transcriptase Inhibitors / adverse effects*
Reverse Transcriptase Inhibitors / blood
Reverse Transcriptase Inhibitors / therapeutic use

Substances

Alkynes
Benzoxazines
Cyclopropanes
Reverse Transcriptase Inhibitors
Aryl Hydrocarbon Hydroxylases
CYP2B6 protein, human
Cytochrome P-450 CYP2B6
Oxidoreductases, N-Demethylating
efavirenz