The polymorphisms Asn130Asp and Val174Ala in OATP1B1 and the CYP2C9 allele *3 independently affect torsemide pharmacokinetics and pharmacodynamics

Clin Pharmacol Ther. 2008 Jun;83(6):815-7. doi: 10.1038/sj.clpt.6100404. Epub 2007 Nov 14.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alanine / genetics
  • Alleles*
  • Aryl Hydrocarbon Hydroxylases / genetics*
  • Asparagine / genetics
  • Aspartic Acid / genetics
  • Cytochrome P-450 CYP2C9
  • Humans
  • Liver-Specific Organic Anion Transporter 1
  • Organic Anion Transporters / genetics*
  • Polymorphism, Genetic / genetics*
  • Sulfonamides / pharmacokinetics*
  • Torsemide
  • Valine / genetics

Substances

  • Liver-Specific Organic Anion Transporter 1
  • Organic Anion Transporters
  • SLCO1B1 protein, human
  • Sulfonamides
  • Aspartic Acid
  • Asparagine
  • CYP2C9 protein, human
  • Cytochrome P-450 CYP2C9
  • Aryl Hydrocarbon Hydroxylases
  • Valine
  • Alanine
  • Torsemide