Where is the evidence that p-glycoprotein limits brain uptake of antiepileptic drug and contributes to drug resistance in epilepsy?

Epilepsia. 2007 Dec;48(12):2372-4. doi: 10.1111/j.1528-1167.2007.01260_3.x.
No abstract available

Publication types

  • Comparative Study
  • Letter
  • Comment

MeSH terms

  • ATP Binding Cassette Transporter, Subfamily B
  • ATP Binding Cassette Transporter, Subfamily B, Member 1 / genetics
  • ATP Binding Cassette Transporter, Subfamily B, Member 1 / metabolism*
  • ATP Binding Cassette Transporter, Subfamily B, Member 1 / physiology
  • Anticonvulsants / pharmacokinetics*
  • Anticonvulsants / therapeutic use
  • Blood-Brain Barrier / metabolism
  • Blood-Brain Barrier / physiology
  • Brain / metabolism*
  • Drug Resistance / genetics
  • Drug Resistance / physiology
  • Drug Resistance, Multiple / genetics
  • Drug Resistance, Multiple / physiology
  • Epilepsy / drug therapy*
  • Epilepsy / genetics
  • Epilepsy / metabolism
  • Humans
  • Phenotype

Substances

  • ABCB1 protein, human
  • ATP Binding Cassette Transporter, Subfamily B
  • ATP Binding Cassette Transporter, Subfamily B, Member 1
  • Anticonvulsants