Abstract
The radial migration is an important process in the development of the cerebral cortex. Earlier studies have reported that classical neurotransmitters such as L-dopamine and L-adrenaline regulate the proliferation of neural progenitor cells. We examined whether L-dopamine and L-adrenaline regulate cell migration, using embryonic neural progenitor cells from mouse embryonic telencephalon in vitro. In this study, we showed that dopamine D1 agonist induces cell migration of embryonic neural progenitor cells. In addition, we have demonstrated that L-adrenaline induces cell migration of embryonic neural progenitor cells, mediated through the activation of alpha-1 adrenergic receptors. Our results suggest that alpha-1 adrenergic receptor and dopamine D1 receptor stimulations in neural progenitor cells are the important process for embryonic brain development, respectively.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adrenergic alpha-1 Receptor Agonists
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Adrenergic alpha-Agonists / pharmacology
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Animals
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Animals, Outbred Strains
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Cell Differentiation / drug effects
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Cell Differentiation / physiology
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Cell Movement / drug effects
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Cell Movement / physiology*
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Dopamine Agonists / pharmacology
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Epinephrine / pharmacology
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Female
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Fluorescent Antibody Technique
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In Vitro Techniques
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Mice
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Neurons / cytology
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Pregnancy
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Receptors, Adrenergic, alpha-1 / metabolism*
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Receptors, Dopamine D1 / agonists
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Receptors, Dopamine D1 / antagonists & inhibitors
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Receptors, Dopamine D1 / metabolism*
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Stem Cells / cytology*
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Stem Cells / physiology
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Telencephalon / cytology
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Telencephalon / embryology
Substances
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Adrenergic alpha-1 Receptor Agonists
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Adrenergic alpha-Agonists
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Dopamine Agonists
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Receptors, Adrenergic, alpha-1
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Receptors, Dopamine D1
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Epinephrine