Abstract
Recent studies of the problem of ictogenesis, or the ways that seizures develop in an already hyperexcitable brain, are leading to paradigm-shifting concepts that may lead to exciting new therapies for seizures. Research on the equally important area of epileptogenesis, or the ways that a normal brain becomes epileptic, is also expanding, but comparable research into translation of laboratory findings into successful clinical interventions for those at high risk needs to be developed.
MeSH terms
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Anticonvulsants / therapeutic use
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Brain / drug effects
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Brain / pathology
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Brain / physiopathology*
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Brain Damage, Chronic / physiopathology
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Electroencephalography* / drug effects
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Epilepsies, Partial / pathology
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Epilepsies, Partial / physiopathology*
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Epilepsies, Partial / prevention & control
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Hippocampus / drug effects
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Hippocampus / pathology
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Hippocampus / physiopathology
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Humans
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Neocortex / drug effects
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Neocortex / pathology
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Neocortex / physiopathology
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Neural Inhibition / physiology
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Risk Factors
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Sclerosis