Abstract
A cDNA for the rat dopamine D3 receptor containing a 113 bp deletion has been isolated. The segment deleted, encompassing the first extracellular loop and third transmembrane domain, alters the reading frame, introducing 19 amino acids not found in the full length receptor followed by a premature stop codon. This novel mRNA encodes a 109 amino acid protein containing two putative transmembrane domains. A similar variant cDNA for the human D3 receptor has also been identified.
Publication types
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Comparative Study
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Animals
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Base Sequence
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Brain / metabolism
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Chromosome Deletion
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Humans
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Molecular Sequence Data
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Oligodeoxyribonucleotides
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Polymerase Chain Reaction
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RNA Splicing*
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RNA, Messenger / genetics*
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RNA, Messenger / isolation & purification
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Rats
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Rats, Inbred Strains
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Receptors, Dopamine / genetics*
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Receptors, Dopamine D2*
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Receptors, Dopamine D3
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Restriction Mapping
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Sequence Homology, Nucleic Acid
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Transcription, Genetic*
Substances
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DRD3 protein, human
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Drd3 protein, rat
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Oligodeoxyribonucleotides
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RNA, Messenger
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Receptors, Dopamine
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Receptors, Dopamine D2
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Receptors, Dopamine D3
Associated data
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GENBANK/M64052
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GENBANK/M64053
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GENBANK/M64054
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GENBANK/M64055
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GENBANK/M64056
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GENBANK/M64057
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GENBANK/M64058
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GENBANK/M64059
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GENBANK/M64060
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GENBANK/S62729