Abstract
Poor response to antipsychotics is still an important problem in the treatment of many schizophrenia patients. N-acetylcysteine (NAC) is a compound that exerts anti-oxidant and scavenging actions against reactive oxygen species. This paper reports a case of poorly responsive schizophrenia patient who improved considerably with add-on NAC 600 mg/day. The NAC might work through activating cysteine-glutamate antiporters or reducing in nitric oxide (NO) metabolites, free radicals and cytokines or through both of these mechanisms.
MeSH terms
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Acetylcysteine / adverse effects
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Acetylcysteine / therapeutic use*
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Adult
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Antipsychotic Agents / adverse effects
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Antipsychotic Agents / therapeutic use*
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Benzodiazepines / adverse effects
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Benzodiazepines / therapeutic use
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Clopenthixol / adverse effects
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Clopenthixol / analogs & derivatives
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Clopenthixol / therapeutic use
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Delayed-Action Preparations
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Dose-Response Relationship, Drug
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Drug Resistance
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Drug Therapy, Combination
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Female
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Free Radical Scavengers / adverse effects
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Free Radical Scavengers / therapeutic use*
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Humans
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Olanzapine
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Psychiatric Status Rating Scales
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Schizophrenia / drug therapy*
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Schizophrenic Psychology*
Substances
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Antipsychotic Agents
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Delayed-Action Preparations
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Free Radical Scavengers
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Benzodiazepines
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clopenthixol decanoate
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Clopenthixol
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Olanzapine
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Acetylcysteine