Effects of methylenedioxymethamphetamine on the release of monoamines from rat brain slices

Eur J Pharmacol. 1990 Nov 27;191(2):217-20. doi: 10.1016/0014-2999(90)94150-v.

Abstract

The effects of 3,4-methylenedioxymethamphetamine (MDMA) on monoamine release were investigated in superfused slices of rat striatum and hippocampus. MDMA (10 microM) increased the resting release of radioactivity from slices incubated in [3H]dopamine, [3H]5-hydroxytryptamine or [3H]noradrenaline. These effects of MDMA (10 microM) were blocked by the neuronal uptake inhibitors, cocaine (10 microM), fluoxetine (1 microM) and desmethylimipramine (1 microM), respectively. MDMA (10 microM) enhanced the stimulation-induced efflux of radioactivity from slices incubated in [3H]noradrenaline but not from slices incubated in [3H]5-hydroxytryptamine or [3H]dopamine. These results demonstrate for the first time a direct noradrenaline-releasing action of MDMA and differential effects of MDMA on the stimulation-induced release of noradrenaline, dopamine and 5-hydroxytryptamine from rat superfused brain slices.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 3,4-Methylenedioxyamphetamine / analogs & derivatives*
  • 3,4-Methylenedioxyamphetamine / pharmacology
  • Animals
  • Corpus Striatum / metabolism*
  • Dopamine / metabolism*
  • Electric Stimulation
  • Female
  • Hippocampus / metabolism*
  • N-Methyl-3,4-methylenedioxyamphetamine
  • Norepinephrine / metabolism*
  • Rats
  • Rats, Inbred Strains
  • Serotonin / metabolism*

Substances

  • Serotonin
  • 3,4-Methylenedioxyamphetamine
  • N-Methyl-3,4-methylenedioxyamphetamine
  • Dopamine
  • Norepinephrine