Abstract
Seminalplasmin, an antimicrobial protein from bovine seminal plasma, inhibited peptidoglycan synthesis in Escherichia coli in a concentration-dependent manner. The inhibition of peptidoglycan synthesis appears to be a cause rather than a consequence of growth inhibition as it was observed soon after the addition of the antibiotic even in E. coli cells whose growth was totally inhibited by chloramphenicol.
MeSH terms
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Animals
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Anti-Bacterial Agents / administration & dosage
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Anti-Bacterial Agents / blood
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Anti-Bacterial Agents / pharmacology*
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Cattle
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Chloramphenicol / pharmacology
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Dose-Response Relationship, Drug
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Escherichia coli / drug effects
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Escherichia coli / growth & development
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Escherichia coli / metabolism*
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Male
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Peptidoglycan / biosynthesis*
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Proteins / administration & dosage
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Proteins / pharmacology*
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Semen / chemistry
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Seminal Vesicle Secretory Proteins*
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Seminal Vesicles / chemistry
Substances
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Anti-Bacterial Agents
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Peptidoglycan
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Proteins
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Seminal Vesicle Secretory Proteins
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Chloramphenicol