Abstract
We have cloned a member of the steroid hormone receptor superfamily of ligand-activated transcription factors. The receptor homologue is activated by a diverse class of rodent hepatocarcinogens that causes proliferation of peroxisomes. Identification of a peroxisome proliferator-activated receptor should help elucidate the mechanism of the hypolipidaemic effect of these hepatocarcinogens and aid evaluation of their potential carcinogenic risk to man.
MeSH terms
-
Amino Acid Sequence
-
Animals
-
Base Sequence
-
Binding Sites
-
Cloning, Molecular
-
DNA / metabolism
-
Gene Expression / drug effects
-
Humans
-
Hypolipidemic Agents / adverse effects
-
Hypolipidemic Agents / pharmacology*
-
Liver / ultrastructure*
-
Liver Neoplasms, Experimental / chemically induced
-
Mice
-
Microbodies / drug effects*
-
Microbodies / ultrastructure
-
Molecular Sequence Data
-
Nafenopin / pharmacology
-
Receptors, Estrogen / genetics
-
Receptors, Estrogen / metabolism
-
Receptors, Glucocorticoid / genetics
-
Receptors, Glucocorticoid / metabolism
-
Receptors, Steroid / drug effects
-
Receptors, Steroid / genetics
-
Receptors, Steroid / metabolism*
-
Sequence Homology, Nucleic Acid
-
Tissue Distribution
Substances
-
Hypolipidemic Agents
-
Receptors, Estrogen
-
Receptors, Glucocorticoid
-
Receptors, Steroid
-
Nafenopin
-
DNA