Inhibition of glycogen synthase kinase-3 is necessary for the rapid antidepressant effect of ketamine in mice

MeSH terms

• Amino Acid Substitution
• Animals
• Antidepressive Agents / pharmacology*
• Cerebral Cortex / drug effects
• Cerebral Cortex / enzymology*
• Depression / drug therapy
• Disease Models, Animal
• Drug Evaluation, Preclinical
• Electroshock
• Gene Knock-In Techniques
• Glycogen Synthase Kinase 3 / antagonists & inhibitors*
• Glycogen Synthase Kinase 3 / chemistry
• Glycogen Synthase Kinase 3 / genetics
• Glycogen Synthase Kinase 3 / physiology
• Glycogen Synthase Kinase 3 beta
• Helplessness, Learned
• Hippocampus / drug effects
• Hippocampus / enzymology*
• Ketamine / pharmacology*
• Lithium Chloride / pharmacology
• Mice
• Nerve Tissue Proteins / antagonists & inhibitors*
• Nerve Tissue Proteins / chemistry
• Nerve Tissue Proteins / genetics
• Nerve Tissue Proteins / physiology
• Phosphorylation / drug effects
• Phosphoserine / metabolism*
• Point Mutation
• Protein Processing, Post-Translational / drug effects