Abstract
Treatment with L-NG-monomethyl arginine (L-NMMA), an inhibitor of nitric oxide (NO) synthesis from L-arginine, suppressed the relaxant response of dog cerebral artery strips to transmural electrical stimulation and nicotine, as did oxyhemoglobin. The inhibition by L-NMMA was reversed or prevented by L-, but not D-, arginine. It is concluded that NO or an NO-related compound may play a crucial role in transmitting information from excited vasodilator nerves to cerebroarterial smooth muscle.
MeSH terms
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Animals
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Arginine / analogs & derivatives
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Arginine / pharmacology
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Cell Communication / drug effects
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Cell Communication / physiology
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Cerebral Arteries / drug effects
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Cerebral Arteries / physiology*
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Chemical Phenomena
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Chemistry
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Dogs
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Electric Stimulation
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Neuromuscular Junction / physiology*
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Nicotine / pharmacology
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Nitric Oxide / metabolism*
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Synaptic Transmission / drug effects
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Synaptic Transmission / physiology*
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Vasodilation / drug effects
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Vasodilation / physiology*
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omega-N-Methylarginine
Substances
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omega-N-Methylarginine
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Nitric Oxide
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Nicotine
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Arginine