Abstract
The cellular localization and the distribution of the mas proto-oncogene/angiotensin receptor mRNA have been studied in the male rat brain using in situ hybridization with radiolabelled mas cRNA probes. Neuronal cell populations in the forebrain were selectively labelled. A strong specific labelling was demonstrated in the dentate gyrus, the CA3 and CA4 areas of the hippocampus, the olfactory tubercle (medical part), the piriform cortex and the olfactory bulb, while a weak to moderate labelling was present all over the neocortex and especially in the frontal lobe.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Autoradiography
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Brain / cytology
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Brain / enzymology*
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Male
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Neoplasm Proteins / genetics*
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Nucleic Acid Hybridization
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Organ Specificity
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Protein-Tyrosine Kinases / genetics
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Proto-Oncogene Mas
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Proto-Oncogene Proteins / genetics*
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Proto-Oncogenes*
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RNA, Messenger / analysis
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RNA, Messenger / genetics*
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Rats
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Rats, Inbred Strains
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Receptors, G-Protein-Coupled
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Sulfur Radioisotopes
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Uridine Triphosphate / metabolism
Substances
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Neoplasm Proteins
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Proto-Oncogene Mas
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Proto-Oncogene Proteins
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RNA, Messenger
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Receptors, G-Protein-Coupled
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Sulfur Radioisotopes
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Protein-Tyrosine Kinases
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Uridine Triphosphate