Galactosylated poly(L-lysine) as a hepatotropic carrier of 9-beta-D-arabinofuranosyladenine 5'-monophosphate

FEBS Lett. 1986 Jul 28;203(2):203-6. doi: 10.1016/0014-5793(86)80742-6.

Abstract

D-Galactopyranosyl residues were coupled to poly(L-lysine) and the antiviral agents arabinofuranosyladenine 5'-monophosphate (ara-AMP) and acyclovir were conjugated with this glycosylated polymer. In mice the ara-AMP conjugate accomplished a selective drug delivery to liver cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acyclovir / administration & dosage
  • Acyclovir / analogs & derivatives
  • Animals
  • Arabinonucleotides / administration & dosage*
  • DNA / biosynthesis
  • Galactose / administration & dosage*
  • Liver / metabolism*
  • Mice
  • Pharmaceutical Vehicles
  • Polylysine / administration & dosage*
  • Serum Albumin / administration & dosage
  • Vidarabine Phosphate / administration & dosage*
  • Vidarabine Phosphate / metabolism

Substances

  • Arabinonucleotides
  • Pharmaceutical Vehicles
  • Serum Albumin
  • Vidarabine Phosphate
  • Polylysine
  • acyclovir monophosphate
  • DNA
  • Galactose
  • Acyclovir