Abstract
D-Galactopyranosyl residues were coupled to poly(L-lysine) and the antiviral agents arabinofuranosyladenine 5'-monophosphate (ara-AMP) and acyclovir were conjugated with this glycosylated polymer. In mice the ara-AMP conjugate accomplished a selective drug delivery to liver cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acyclovir / administration & dosage
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Acyclovir / analogs & derivatives
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Animals
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Arabinonucleotides / administration & dosage*
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DNA / biosynthesis
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Galactose / administration & dosage*
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Liver / metabolism*
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Mice
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Pharmaceutical Vehicles
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Polylysine / administration & dosage*
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Serum Albumin / administration & dosage
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Vidarabine Phosphate / administration & dosage*
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Vidarabine Phosphate / metabolism
Substances
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Arabinonucleotides
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Pharmaceutical Vehicles
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Serum Albumin
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Vidarabine Phosphate
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Polylysine
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acyclovir monophosphate
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DNA
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Galactose
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Acyclovir