Abstract
The mesoporous silicon microparticles (MSMPs) are excellent vehicles for releasing molecules inside the cell. The aim of this work was to use MSMPs to deliver viral specific MHC class I restricted epitopes into human antigen presenting cells (monocyte derived dendritic cells, MDDCs) to facilitate their capture, processing, and presentation to CD8+ (cytotoxic) T lymphocytes. We show for the first time that MSMPs vehiculation of antigenic peptides enhances their MHC class I presentation by human MDDCs to CD8 T lymphocytes.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antigen Presentation / immunology*
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Antigen-Presenting Cells / immunology
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Antigens, Viral / chemistry
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Antigens, Viral / immunology
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Calcium Compounds* / chemistry
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Cells, Cultured
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Dendritic Cells / immunology*
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Dendritic Cells / metabolism
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Epitopes / administration & dosage
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Epitopes / immunology
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Histocompatibility Antigens Class I / immunology*
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Humans
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Nanoparticles* / chemistry
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Nanoparticles* / toxicity
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Nanoparticles* / ultrastructure
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Particle Size
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Peptide Fragments / administration & dosage
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Peptide Fragments / chemistry
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Peptide Fragments / immunology
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Silicates* / chemistry
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Surface Properties
Substances
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Antigens, Viral
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Calcium Compounds
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Epitopes
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Histocompatibility Antigens Class I
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Peptide Fragments
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Silicates
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calcium silicate