Abstract
Calcium is released from the isolated heavy sarcoplasmic reticulum (SR) of frog skeletal muscle upon application of 0.1-1 mM diethylpyrocarbonate (DEP, an imidazolyl reagent). The Ca-ATPase activity of SR was suppressed by 20% in the presence of 1 mM DEP. More than 1 mM of free magnesium ion or 5 microM ruthenium red eliminated the effect of DEP on calcium release but not on Ca-ATPase activity. A plausible site of DEP action is on the calcium channel.
MeSH terms
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Animals
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Calcium / metabolism*
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Calcium-Transporting ATPases / antagonists & inhibitors
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Diethyl Pyrocarbonate / pharmacology*
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Formates / pharmacology*
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Magnesium / pharmacology
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Muscles / drug effects
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Muscles / metabolism*
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Rana catesbeiana
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Ruthenium Red / pharmacology
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Sarcoplasmic Reticulum / drug effects
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Sarcoplasmic Reticulum / metabolism*
Substances
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Formates
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Ruthenium Red
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Calcium-Transporting ATPases
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Magnesium
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Diethyl Pyrocarbonate
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Calcium