Abstract
In three of eight patients with the acquired immune deficiency syndrome the Pneumocystis carinii pneumonia treated with intravenous trimethoprim sulfamethoxazole, drug-related reactions occurred 9, 10, and 13 days after therapy. The symptom complex consisted of a maculopapular eruption, fever, eosinophilia, and leukopenia. Oral desensitization with graded doses of trimethoprim sulfamethoxazole was successfully achieved in two of the three patients.
MeSH terms
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Acquired Immunodeficiency Syndrome / complications*
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Administration, Oral
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Adult
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Anti-Infective Agents / adverse effects*
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Desensitization, Immunologic*
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Drug Combinations / administration & dosage
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Drug Combinations / adverse effects
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Drug Eruptions / etiology
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Drug Eruptions / prevention & control
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Drug Hypersensitivity / etiology
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Drug Hypersensitivity / prevention & control*
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Humans
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Male
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Pneumonia, Pneumocystis / drug therapy*
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Sulfamethoxazole / administration & dosage
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Sulfamethoxazole / adverse effects*
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Trimethoprim / administration & dosage
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Trimethoprim / adverse effects*
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Trimethoprim, Sulfamethoxazole Drug Combination
Substances
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Anti-Infective Agents
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Drug Combinations
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Trimethoprim, Sulfamethoxazole Drug Combination
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Trimethoprim
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Sulfamethoxazole