Abstract
Addition of alkaline phosphatase and WR-2721 to culture medium containing V79-171 cells leads to production of WR-1065 and its disulphide forms in the medium, to cellular accumulation of WR-1065, and to radioprotection which correlates with cellular WR-1065 level.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Alkaline Phosphatase / pharmacology*
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Amifostine / metabolism*
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Animals
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Cell Line
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Cell Survival / drug effects
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Cell Survival / radiation effects*
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Cesium Radioisotopes
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Cricetinae
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Cricetulus
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Gamma Rays
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In Vitro Techniques
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Mercaptoethylamines / metabolism*
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Mercaptoethylamines / pharmacology
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Organothiophosphorus Compounds / metabolism*
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Radiation-Protective Agents / pharmacology*
Substances
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Cesium Radioisotopes
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Mercaptoethylamines
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Organothiophosphorus Compounds
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Radiation-Protective Agents
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N-(2-mercaptoethyl)-1,3-diaminopropane
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Alkaline Phosphatase
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Amifostine