Abstract
Superoxide generation by guinea pig macrophages and polymorphonuclear leukocytes induced by wheat germ agglutinin, immune complexes or formyl-methionyl-leucyl-phenylalanine was inhibited considerably by 3'-deazaadenosine. The pre-exposure of the 3'-dezazaadenosine-treated cells to a small amount of phorbol myristate acetate abolished the inhibitory effect of 3'-deazaadenosine on the generation of superoxide.
MeSH terms
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Animals
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Antigen-Antibody Complex
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Dose-Response Relationship, Drug
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Guinea Pigs
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Lectins / pharmacology
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Macrophages / drug effects
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Macrophages / metabolism
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N-Formylmethionine Leucyl-Phenylalanine / pharmacology
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Neutrophils / drug effects
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Neutrophils / metabolism
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Phagocytes / drug effects
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Phagocytes / metabolism*
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Phorbols / pharmacology*
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Ribonucleosides / pharmacology*
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Superoxides / metabolism*
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Tetradecanoylphorbol Acetate / pharmacology*
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Tubercidin / pharmacology*
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Wheat Germ Agglutinins
Substances
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Antigen-Antibody Complex
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Lectins
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Phorbols
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Ribonucleosides
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Wheat Germ Agglutinins
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3-deazaadenosine
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Superoxides
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N-Formylmethionine Leucyl-Phenylalanine
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Tubercidin
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Tetradecanoylphorbol Acetate