Abstract
17-oxidation and 2- and 16 alpha-hydroxylation of oestradiol show important correlations with biological aspects of breast cancer in women and mice. The presence of mouse mammary tumour virus may lead to increased 16 alpha-hydroxylation. 16 alpha-hydroxyoestrone (which may be generated in an autocrine manner) forms covalent linkages with amino groups on proteins and nucleotides.
MeSH terms
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Animals
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Aryl Hydrocarbon Hydroxylases*
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Breast Neoplasms / enzymology*
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Estrogens / metabolism
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Female
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Humans
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Male
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Mammary Neoplasms, Experimental / enzymology
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Mammary Tumor Virus, Mouse
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Menopause
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Mice
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Mice, Inbred Strains
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Risk
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Steroid 16-alpha-Hydroxylase*
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Steroid Hydroxylases / analysis*
Substances
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Estrogens
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Steroid Hydroxylases
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Aryl Hydrocarbon Hydroxylases
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Steroid 16-alpha-Hydroxylase