Abstract
The trypanocide Suramin was tested as a possible antagonist at the P2-purinoceptor of the mouse vas deferens. At a concentration of 100 microM, Suramin antagonized the response to alpha,beta-methylene ATP, while responses to carbachol and noradrenaline were unaffected. These results suggest that Suramin may provide a starting point for the development of specific antagonists for P2-purinoceptors.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenosine Diphosphate / analogs & derivatives
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Adenosine Diphosphate / pharmacology
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Animals
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In Vitro Techniques
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Male
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Mice
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Mice, Inbred C57BL
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Muscle Contraction / drug effects
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Muscle, Smooth / drug effects*
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Receptors, Purinergic / drug effects*
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Suramin / pharmacology*
Substances
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Receptors, Purinergic
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alpha,beta-methyleneadenosine 5'-diphosphate
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Suramin
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Adenosine Diphosphate